Epidural-related maternal fever (ERMF) occurs in ~26% of women who receive epidural analgesia during labour. Intra-partum fever is associated with more frequent obstetric interventions, ~30% higher rate of (unnecessary) antibiotic administration, lower rates of spontaneous vaginal delivery, and excess neonatal morbidity.

This observational study will identify whether epidural-related maternal fever is more common in women with gene polymorphisms for IL-1Ra (~20% of the general population). In future NIHR applications, we would use this genomic approach to demonstrate that obstetric anaesthesia can be shaped by precision medicine to reduce obstetric interventions and limit antibiotic use.

  • If you are interested in participating in the trial please contact Prof Gareth Ackland g.ackland@qmul.ac.uk