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RESULT-Hip: The impact of Restrictive versus Liberal Transfusion strategy on cardiac injury in patients undergoing surgery for Hip Fracture

Anaemia is common in patients who have sustained a hip fracture, and 30-40% of these patients receive a blood transfusion before or after surgery. Many of these older patients also suffer cardiac complications after their hip fracture which affect morbidity and mortality: cardiac complications are more common in anaemic patients. Blood transfusions to optimise cardiac oxygen delivery may help to prevent cardiac complications and result in improved outcomes.

Result-Hip is a multicentre randomised controlled trial comparing the effect of two perioperative transfusion strategies on the incidence of death and cardiac injury (major adverse cardiac events, MACE) after emergency hip fracture surgery. We will recruit 1,964 patients who have become anaemic after presenting to hospital with a hip fracture. Half of these patients will be randomised to receive blood transfusion at a higher anaemia level, when the haemoglobin is 90g/L or less, and the others will receive blood transfusions when the haemoglobin measures 75g/L or less. The primary outcome is death and MACE within 30 days of surgery. The secondary outcomes include other complications, duration of hospital stay, quality of life, mobility, and economic health evaluation. We will compare outcomes between the groups in order to determine best management and guide how blood transfusions are given in the future.

More information about the study is available at

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